Comparison of Human and Murine Enteroendocrine Cells by Transcriptomic and Peptidomic Profiling
Comparison of Human and Murine Enteroendocrine Cells by Transcriptomic and Peptidomic Profiling
Enteroendocrine cells (EECs) produce hormones such as glucagon-like peptide 1 and peptide YY that regulate food absorption, insulin secretion, and appetite. Based on the success of glucagon-like peptide 1–based therapies for type 2 diabetes and obesity, EECs are themselves the focus of drug discovery programs to enhance gut hormone secretion. The aim of this study... Read more Read more
Melatonin Increases Brown Adipose Tissue Volume and Activity in Patients With Melatonin Deficiency: Study
Melatonin Increases Brown Adipose Tissue Volume and Activity in Patients With Melatonin Deficiency: Study
Melatonin, a pineal hormone synthesized at night, is critical for the synchronization of circadian and seasonal rhythms, being a key regulator of energy metabolism in many animal species. Although studies in humans are lacking, several reports, mainly on hibernating animals, demonstrated that melatonin supplementation and a short photoperiod increase brown adipose tissue (BAT) mass. Source: Melatonin... Read more Read more
Key to type 2 diabetes remission may be loss of half a gram of pancreas fat
Key to type 2 diabetes remission may be loss of half a gram of pancreas fat
Adults with type 2 diabetes may be able to achieve sustainable remission from the disease by losing weight and decreasing fat in the pancreas and liver, according to data presented at the Read more
Endocrine diseases ‘emerging epidemic’ after immune checkpoint inhibitor therapies
Endocrine diseases ‘emerging epidemic’ after immune checkpoint inhibitor therapies
Recently approved immune checkpoint inhibitor therapies are now increasingly used for a variety of cancers and other conditions, yet clinicians are only beginning to confront a range of endocrinopathies triggered by such treatments, including thyroid disease, pituitary disorders and insulin-dependent diabetes, according to a speaker here. Source: Endocrine diseases ‘emerging epidemic’ after immune checkpoint inhibitor... Read more Read more
Linagliptin Does Not Increase Adverse Renal Events in Patients With T2D, Kidney Disease
Linagliptin Does Not Increase Adverse Renal Events in Patients With T2D, Kidney Disease
Treatment with linagliptin in patients with type 2 diabetes and cardiovascular and/or kidney disease had no impact on risk for cardiovascular or kidney events. Source: Linagliptin Does Not Read more
Effect of Dietary and Supplemental Omega‐3 Polyunsaturated Fatty Acids on Risk of Recurrent Gout Flares
Effect of Dietary and Supplemental Omega‐3 Polyunsaturated Fatty Acids on Risk of Recurrent Gout Flares
To determine the relationship between omega‐3 polyunsaturated fatty acid (n‐3 PUFA) consumption (dietary or supplemental) and risk of gout flares. Source: Effect of Dietary and Read more
A Practical Guide to Delivering Nutritional Advice to People with Diabetes
A Practical Guide to Delivering Nutritional Advice to People with Diabetes
  Dietary advice is fundamental to the management of diabetes. Although ideally such advice should be delivered by a state-registered dietitian, it is more usually delivered by other health professionals. The primary focus for those with type 1 diabetes is carbohydrate counting and insulin adjustment and for the majority of people with type 2 diabetes,... Read more Read more
Blatant Dehumanization of People with Obesity
Blatant Dehumanization of People with Obesity
Stigmatization of obesity is common, but whether this stigma extends to people with obesity also being considered less human than individuals without obesity has not been examined. This Read more
Colchicine May Improve Obesity-Induced Inflammation
Colchicine May Improve Obesity-Induced Inflammation
Colchicine is safe and effective at improving obesity-associated inflammatory measures among adults with obesity and metabolic syndrome (MetS) without diabetes, according to a pilot study Read more
2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease: Executive Summary
2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease: Executive Summary
The most important way to prevent atherosclerotic vascular disease, heart failure, and atrial fibrillation is to promote a healthy lifestyle throughout life. Source: 2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease: Executive Read more