Weight Management

Wegovy costs $1.1m to prevent one heart attack, stroke, or cardiovascular death | Airfinity
Airfinity analysis on data from the Wegovy trial on cardiovascular outcomes reveals that even after a 65% rebate on the list price, it will cost $1.1m to prevent one heart attack, stroke or Read more
The Unbearable Whiteness and Fatphobia of “Anti-Diet” Dietitians
As unfair as it is to judge 90,000 dietitians-all diverse human beings based on a few wrong-headed social media posts, RD/RDNs need to hear this very angry writer. Read On Medium
Weight Loss: Helping Your Patients Find Their Own Motivation
In part 2 of this podcast, Eileen O’Grady, PhD, RN, NP, talks about realistic goal-setting for weight loss, how to spark motivation in your patients, and overcoming setbacks. Read more
Urban Legends in Bariatric Nutrition
  No matter your area of practice, you likely encounter patients who have had bariatric surgery. While this treatment has greatly evolved over time, bariatric nutrition research has been lacking in some areas leaving room for urban legends. In some cases, protocols are passed from one generation of clinicians to the next with limited evidence… Read more Read more
MC4R – a key regulator of body weight
The Melanocortin 4 Receptor is a key regulator of body weight. People with genetic mutations in MC4R tend to gain weight from early childhood. Source: Melanocortin 4 Receptor | Welcome to Read more
Can Prescription Drugs Cause Weight Gain? 
A list of common prescription drugs that may lead to weight gain. Source: Can Prescription Drugs Cause Weight Gain? – Read more
Experimental Drug Switches Off Hunger in Patients with Genetic Obesity
Investigator-initiated Phase II study finds setmelanotide therapy in patients with leptin receptor gene mutations leads to dramatic reductions in appetite and body weight. Source: Read more
Long-Term Weight Loss Maintained at 15 Years With Metformin
The goal of this study was to identify predictors of long-term weight loss (LTWL) in patients who initially lost weight in one of three programs, for the improvement of weight management over 15 years. Source:Long-Term Weight Loss Maintained at 15 Years With Read more
Fermentation potential of the gut microbiome: implications for energy homeostasis and weight management.
Energy homeostasis is regulated by twin factors, energy intake and energy expenditure. Obesity arises when these two factors are out of balance. Recently, the microflora residing in the Read more
Melatonin Increases Brown Adipose Tissue Volume and Activity in Patients With Melatonin Deficiency: Study
Melatonin, a pineal hormone synthesized at night, is critical for the synchronization of circadian and seasonal rhythms, being a key regulator of energy metabolism in many animal species. Although studies in humans are lacking, several reports, mainly on hibernating animals, demonstrated that melatonin supplementation and a short photoperiod increase brown adipose tissue (BAT) mass. Source: Melatonin… Read more Read more
FDA approves hydrogel pill for overweight, obesity
The FDA on Tuesday approved an oral hydrogel therapy that induces feelings of fullness without adding calories for adults with overweight and obesity, according to a press release from Gelesis. Source: FDA approves hydrogel pill for overweight, Read more
How an Injection of Tiny Beads into Stomach Arteries Might Help with Weight Loss
An experimental obesity treatment that involves injecting tiny beads into the arteries of the stomach may help some people lose weight and keep it off for at least a year, according to a new study. Source: How an Injection of Tiny Beads into Stomach Arteries Might Help with Weight Read more
Patient Behaviors Identified That Impact Weight Regain After RYGB
Several patient behaviors are associated with weight regain after Roux-en-Y gastric bypass (RYGB) surgery, including sedentary time, eating fast food, and eating when feeling full, Read more
Dietary fat, fibre, satiation, and satiety—a systematic review of acute studies
  Humans appear to have innate energy regulation mechanisms that manifest in sensations of satiation during a meal and satiety post ingestion. Interactions between these mechanisms and the macronutrient profile of their contemporary food environment could be responsible for the dysregulation of this mechanism, resulting in a higher energy intake. The aim of this systematic… Read more Read more
Primary care weight-management intervention leads to sustained type 2 diabetes remission
Adults with type 2 diabetes and obesity assigned to a structured weight-management program in a primary care setting were more likely to achieve sustained disease remission at 2 years compared with adults assigned to usual care, according to findings published in The Lancet Diabetes & Endocrinology. Source: Primary care weight-management intervention leads to sustained type… Read more Read more
Meal timing and obesity: interactions with macronutrient intake and chronotype
Timing of dietary intake may play a role in obesity. However, previous studies produced mixed findings possibly due to inconsistent approaches to characterize meal timing and not taking into account chronotype and macronutrients. To address the aforementioned limitations, we have defined meal timing relative to sleep/wake timing, investigated the relationship between meal timing and body… Read more Read more
Weight Science: Evaluating the Evidence for a Paradigm Shift
Current guidelines recommend that “overweight” and “obese” individuals lose weight through engaging in lifestyle modification involving diet, exercise and other behavior change. This approach reliably induces short term weight loss, but the majority of individuals are unable to maintain weight loss over the long term and do not achieve the putative benefits of improved morbidity… Read more Read more
Rate of change in childhood BMI predicts adult obesity risk
The rate of change in BMI at different ages during childhood, particularly during and after puberty, is differentially associated with adult obesity, independent of absolute BMI values at corresponding ages, according to findings from a longitudinal analysis published in Pediatric Obesity. Source: Rate of change in childhood BMI predicts adult obesity Read more
Gelesis100 shows promise for weight loss in adults with obesity
Consistent administration of Gelesis100, a nonsystemic, superabsorbent hydrogel in oral capsule form, can double the odds for meaningful weight loss in adults with overweight or obesity compared with lifestyle modifications alone, according to findings published in Obesity. Source: Gelesis100 shows promise for weight loss in adults with Read more
U.S. Coverage for Adult Obesity Treatment Modalities
Relative to adults without obesity, adults with obesity (BMI ≥ 30 kg/m²) incur 42% higher medical costs¹ and are nearly twice as likely to die before age 70.² Intensive behavioral therapy, nutritional therapy, pharmacotherapy, and bariatric surgery are evidence-based strategies that support clinically-significant weight loss ( ≥ 5% reduction in body weight).³ Nonetheless, coverage for… Read more Read more
Is there a causal relationship between obesity and puberty?
The onset of puberty in adolescents and whether it is related to obesity is an ongoing topic for debate. Epidemiological cross-sectional and longitudinal studies show a shift towards earlier onset of puberty in girls who are obese; however, the situation is less clear in boys. Boys who are overweight seem to mature earlier, and boys who are obese mature later, than… Read more Read more
In PsA, Treat Excessive Weight
Obese patients with psoriatic arthritis (PsA) who followed a short-term, very low-energy diet showed improvements in multiple aspects of disease activity, a prospective study found. Source: In PsA, Treat Excessive Read more
Intermittent Fasts Plus Energy Restriction Best for Weight Loss
Intermittent fasting with restricted energy intake may provide better outcomes than daily continuous diet restriction for health and weight loss in obese women, according to a study Read more