Insulin onset and duration

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Insulin preparation Onset of action Peak Duration of action
Glusaline (Apidra)  10-30 minutes  1/2- 2 hours  3-5 hours
Lispro (Humalog) <15 minutes 1-2 hours 3-6 hours
Aspart (Novolog) <15 minutes 1-2 hours 3-6 hours
Glulisine (Apidra) <15 minutes 1-2 hours 3-6 hours
Regular (Novolin R, Humulin R) 30-60 minutes 2-4 hours 6-10 hours
Humulin R Regular U-500 (500 units/ml) 30-60 minutes 2-4 hours Up to 24 hours
NPH (Novolin N, Humulin N, ReliOn) 2-4 hours 4-8 hours 10-18 hours
Glargine (Lantus) 1-2 hours Usually no peak Up to 24 hours
Detemir (Levemir) 1-2 hours Usually no peak ** Up to 24 hours**
Glargine Injection (300units/ml Toujeo) 6 hours No true peak 24-36 hours
Degludec (Tresibia 200units/ml) 6 hours No peak Up to 42 hours
Premixed Insulins Onset of action Peak Duration of action
Novolin 70/30,
Humulin 70/30
30-60 minutes 2-10 hours 10-18 hours
Humalog 75/25,
Novolog 70/30,
Humalog 50/50
10-30 minutes 1-6 hours 10-14 hours

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